Hisoka Morow is a Antagonist in both the 2011 and 1999 Anime adaptations of Hunter X Hunter

Starting off easy with Hunter X Hunter

Who's the Villain?

While it can be debated whether Kyubey is truly a bad guy, he is the main antagonist of both the 2011 series and the 2013 sequel

Vincent Volaju is the main antagonist of Cowboy Bebop: The Movie

Shindo Ainosuke, or Adam is the main antagonist of Sk8 the Inifnity

Yakushi Kabuto is a major antagonist of the Naruto Franchise

Queen Beryl is the major antagonist in the first arc of Sailor Moon

Enel (Eneru) is the main antagonist of the Skypiea Arc

Dio Brando is the main antagonist of the JJBA Anime

Ryomen Sukuna is the main antagonist of the JJK franchise.

Kibutsuji Muzan, the Demon King is the main antagonist of the KNY Franchise

Shigaraki Tomura and Shigaraki Zen are the main Antagonists of the MHA Franchise.

Anti-Spiral is the main antagonist of the series.

Million Knives is the main antagonist of both the 1998 and 2023 adaptation.

Akazawa Izumi is the main antagonist of the series.

Father/ Dwarf in the Flask is the main antagonist of the series.

 Haruhara Haruko is the main antagonist of the Franchise.

Frieza is the MAIN antagonist of Dragon Ball Z.

Ikari Gendo is the main antagonist of the Franchise.

Griffith is the main antagonist of the Berserk Franchise.

Work In Progress
Tried to have a nice mix of different animes.