Despite being the main antagonist of the Street Fighter Franchise, Bison was not present in the initial title : He was introduced as Vega in the japanese arcade release of Street Fighter II : The World Warrior, as the final of the four unplayable bosses.

From which video game is this character the main villain or final boss ?

Heihachi Mishima was the final boss of the initial Tekken.

Vaas Montenegro, ruler of the first gang Jason Brody (the player's character) faces in Far Cry 3 in a quest to find his brother. Vaas is one of the most popular villains of the franchise, and often quoted among the best written villains of modern era.

Garuda was created by Arika, the developper of the Street Fighter EX, as the initial main antagonist of their roster. Despite sharing the spot with Capcom's M.Bison, he often ends up as the main boss for the Arika characters.

Meet Darth Malak, the final enemy from Star Wars : The Old Republic.

Sagat, for those who didn't know, was the final boss of Street Fighter I.

The eponymous video game, released in 1999 for both PC and PlayStation, follows Qui-Gon, Obi-Wan, Padmé Amidala and her guard captain Panaka as they live the movie's events, leading up to the famed Duel of the Fates against Darth Maul.

Shao Kahn, the most emblematic Mortal Kombat villain, actually is - like his Street Fighter counterpart M.Bison - only the final boss of the second opus of his franchise.

Jack of Blades, the initial game's main villain. A complex history which even deepened as the trilogy unfolded, revealing the mastermind behind it all in the third opus.

Wolfgang Krauser von Stroheim, introduced in Fatal Fury 2 as the replacement final boss for Geese Howard, similarly to Street Fighter with Bison and Sagat. Krauser is known for insane strength and force, imposing height and nobility.

Akuma, known as his "real" name Gouki in Japan, is the 17th character of the Street Fighter II series, and was added as the secret final boss met only when the player successfully defeated all his opponents (until Sagat) without losing one bout. He was the last addition to the Street Fighter II roster until Evil Ryu and Violent Ken in the latest installment of the series, "Ultra Street Fighter II".

Darth Traya, the biggest threat to the Star Wars Galaxy around 3945 before the Battle of Yavin.

Star Wars : Knights of the Old Republic II

Despite changing forms, Ogre and its true form was the main antagonist and the final enemy of the franchise's third installment.

Tavion Axmis was a side villain in the series' previous installment, and the main villain of Jedi Academy. Despite being possessed by the Grand Marka Ragnos' spirit, she still was the person trying to kill Jaden Korr, the opus' titular character.

"This" being the female character on the right.

Meet Dr. Wily, creator of most of the enemies Megaman faces in the decades-long series

Unknown, who served as the final boss for both Tekken Tag games. She wasn't there in the meantime, and it isn't confirmed whether she is Jun Kazama or not.

Geese Howard was, like Street Fighter's Sagat and Mortal Kombat's Shang Tsung, the initial final boss and the second to last of his franchise's second opus. But unlike the aforementioned two, he succeeded becoming his franchise's main villain, somehow eclipsing his alter-ego Wolfgang Krauser as he's the only King of Fighters villain who crossed over to Tekken and Street Fighter.

Ganondorf, the main villain and final boss of the first three Zelda games.

Guess the video game from a picture (either live-action or cosplay) of it's main villain or final boss. But beware of the franchise traps ! I'm asking you the title of the very game he/she was the main villain or final boss in, not the overall franchise !